Letting Nature Decide

Introduction Genetic diseases are inheritable diseases which can be passed from the parents to the offspring’s. Hereditary diseases are very harmful when allowed to run through generation. If there is history of a genetic disorder within their family, they should ensure that they take the necessary steps to minimize it without necessarily going for a DNA test. The most important way is to avoid marriage unions within the family institution.Advertising We will write a custom essay sample on Letting Nature Decide specifically for you for only $16.05 $11/page Learn More Secondly, the family should learn how to interact with people with such disorders to prevent further spreading. The paper is going to outlines some of the genetic disorders, what causes them and necessary measures of treatment. The paper will also discuss reasons as to why parents should not have their DNA tested, why those with higher chances of getting genetic disorders should not b e charged more by insurance companies and finally support the fact that people who refuse to have their DNA tested should not pay more to insurance companies. Genes Genes are molecular units that carry the hereditary material in an organism. They are segments of the DNA that determine the characteristics of individuals. For instance, physical characteristics like body size, height and color are determined by genes. Genetic disorders are also passed from the parent to the offspring. The individual inherits some of the characteristics from the mother and the rest is inherited from the father. Heredity plays a major role in determining whether an individual will be bright or a great athlete among other abilities. However, the environment in which an individual is exposed to may be of great influence to his/her interests and abilities. These include the kind of people an individual interacts with, foods and substances consumed and place of residence. Sometimes changes occur in the compo sition of genes in a process called mutation. Mutation occur when genes are growing old or due to exposure to chemicals and radiation. Mutations are however detected by cells and repaired. Gene mutations cause diseases if not repaired. Children inherit mutated genes from the sperm and egg cells of their parents (Lashley, 2005). Genetic Disorders Genetic disorders arise as a result of abnormal functioning of genes. Human body carries harmful genes. Some of these genes are recessive such that people may not realize that they carry them. Effects of the genes will be felt only after exposure to environmental changes. However, the effects of some genes are manifested before or from the birth of a child.Advertising Looking for essay on anthropology? Let's see if we can help you! Get your first paper with 15% OFF Learn More According to a study conducted by the Royal College of Physicians in the United Kingdom, about 3% of the total number of children is born with genetic dis orders. It is approximated that a population of about 13,000 births suffer from genetically related diseases in the United Kingdom. The condition may take some time before manifesting itself or it may manifest itself during the early stages of life (Swarts, 2009). Causes of genetic disorders Genetic disorders are caused by many factors. Genetic disorders may be passed from the parents to the offspring’s during the process of fertilization. If one of the parents has a genetic disorder, he/she may pass the disorder to the unborn child. The chances of getting the disorder are even higher when both parents have the disorder. Examples of inheritable diseases include sickle cell anemia and hemophilia. Secondly, the environment in which an individual lives increasing the chances of contracting genetic diseases. People living in mosquito breeding areas where malaria attacks are high are likely to contract sickle cell anemia. The disease is characterized by sticking together of the he moglobin producing blood cells in the shape of a sickle. The body does not have sufficient supply of oxygen because red blood cells are few. Some of the genetic diseases like tuberculosis are air-born. Living in poorly ventilated houses with such people increases the chances of getting the disease. Sharing personal items like clothing and utensils may also lead to attacks (Doak, 2011). Some people are allergic to some things like foods, smells and dust. Exposure to such things may lead to genetic disease. For instance some people get tuberculosis out of dust allergies. Climatic changes may influence individual health negatively. Movement of people to new areas increases the chances of getting some diseases. Finally, meiosis may contribute to genetic diseases. The process involves combination of genes during which exchange of genetic materials takes place. Problems occur when chromosomes undergo abnormal combination. For instance, some information may be lost (deletion), inverted (tr anslocation) or multiplied (duplication). Diseases related to abnormal combination of chromosomes include Cri du Chat syndrome and Down syndrome (Doak, 2011). Treatment of Genetic Disorder Genetic diseases cannot be cured but medical measures can be applied to minimize its effects. For example, Porphyria variegate is a genetic disease commonly found in South Africa. Victims find it hard to walk during the day because the effects of the sun make them develop rashes on their skin.Advertising We will write a custom essay sample on Letting Nature Decide specifically for you for only $16.05 $11/page Learn More However, staying in shade is the solution to the problem. Staying in a shade does not mean that the person is cured because he/she is still carrying the gene (Swarts, 2009). Transfusion is a treatment measure towards sickle cell anemia victims, but the condition is not cured. Breast cancer is another disease which runs through generations. Patients are treated through the removal of the breast but this does not cure the person because she is still carrying the gene responsible for the disease and can as well pass it to her children. Genetic counseling is important so that individuals and families make wise decisions. Genetic counselors have knowledge of how genetic diseases are passed from parents to the offspring and therefore of great help to couples who would wish to get children. Depending on individual’s genetic composition, the counselor advice them on the probability of passing genetic disease to their offspring’s (Swarts, 2009). Effects of genetic diseases Genetic disorders cause anxiety and worry to the victims. Parents are worried that they may pass the disease to their children. People may react angrily to people for not telling their state in advance. This can cause divorce. The victims are always depressed. They do not know whether or not their children will get the disease. Termination off pregnancies due to attacks may also put the victim in a condition of stress. Parents have a feeling of guilt whenever they see their children suffering because they are the cause of the suffering. Some victims of genetic disorders live in isolation because the diseases are communicable. They suffer from loneliness. Lack of interaction with other people makes them feel that they are lesser beings. Lastly victims are always uncertain of whether they are at risk of genetic condition or they will test positive to the genetic disorder (Swarts, 2009). According to me, parents should not hesitate to go for the advice because it is a preventive measure. However, individuals should not go for the test to determine whether or not they have any genetic disorder. This is because they will have nothing to do after knowing their condition. Since it is in their genetic makeup, the condition will remain even after they are aware.Advertising Looking for essay on anthropology? Let's see if we can help you! Get your first paper with 15% OFF Learn More In addition, some people get stressed up after getting to know that they suffer from diseases which cannot be cured. Stress and emotional discomfort may trigger other health related diseases. Some will think that they have limited days of living without knowing that they can live for many years in that condition. Why then should people want to know what will stress them for the rest of their lives? According to Milunsky Milunsky (2011) studies have shown that not all people diagnosed with gene carrying disorder contact the diseases. There are many people whose genes carry disorders but neither them nor any of their family members have been found with the disease. Since it’s not a must to get the disease, then why get tested.Many people discriminate against people with genetic disorders. Some may not want to interact with such people. Failure to undergo the test reduces stigmatization because none is aware of individual’s condition. Many people will never marry from su ch families once they are aware. Even if people are no0t diagnosed with the disease, the environment in which they live in may expose them to diseases. Lastly, treatment of genetic disorders is costly and the concerned may not be able to raise enough money if diagnosed with a genetic disorder. People should just wait for the signs of the disease to show. Parents whose probability of getting children with medical problems is high should not pay more premiums for their health insurance. The fact that they show great chances of having children with disorders is not a guarantee that they will bring up sickly children. Their children can also be normal. In addition, people suffering from other diseases may spend more in their treatments that those with genetic disorders. Since it’s difficult to predict how much an individual will spent, the insurance premium should be universal for people (Milunsky Milunsky, 2011). Moreover, people who refuse to undergo the test should equally pa y health insurance premium. Even if they went for the test, they will not change their condition. This is because whether they undergo the test or not, they will pay the premium which will cover their health insurance. Testing should be individual’s choice (Milunsky Milunsky, 2011). Conclusion The paper has outlined some of the diseases which are passed from parents to the parents to the offspring during the process of fertilization as well as other factors which put individual’s risk of contracting such diseases. The paper has also discussed treatment measures of some genetic diseases. Even though genetic diseases cannot be cured, there are solutions to such problems. The paper has outlined reasons as tp why parents should not go for a DNA test. Finally the paper argues against imposition of higher charges against people at greater risk of getting genetic diseases and those who refuse to undergo the test by health insurance companies. References Doak, R. (2011). Gene tic disorders. London: Benchmark Education Company. Lashley, R. (2005). Clinical genetics in nursing practice. New York, NY: Springer Publishing Company. Milunsky, A. Milunsky, J. (2011). Genetic disorders and the fetus: Diagnosis, prevention and treatment. New York: Springer Publishing Company. Swarts, K. (2009). Genetic disorders. New York, NY: Greenhaven Press. This essay on Letting Nature Decide was written and submitted by user Lauren D. to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

Past Participles in English Grammar

Past Participles in English Grammar In English grammar, the past participle refers to an action that was started and completed entirely in the past. It is the third principal part of a verb, created by adding -ed, -d, or -t to the base form of a regular verb. The past participle is generally used with an  auxiliary  (or helping) verb- has, have, or  had- to express the  perfect aspect, a  verb  construction that describes events occurring in the past that are linked to a later time, usually the present. In addition to the perfect aspect (or perfect tense), the past participle  can be used in a  passive voice  or as an  adjective. Past Participles of Regular Verbs To understand past participles, you first need to know how to make a verb  past tense, says  Study.com. To do so, simply add ed, d, or t, as in these examples that show the verb on the left and the simple past tense on the right: Help helpedWeep weptWork worked Turning these verbs into past participles is also simple: Make the verb past tense and precede it with an  auxiliary verb, as in these examples that list the simple past on the left and the past participle on the right: Helped have helpedVisited have visitedWorked have worked Though they may seem similar, there is a  difference between regular past tense and past participle. The regular past has only one part while the past participle always has two or more parts, and as noted, generally requires an auxiliary verb, says  Write.com. An example of a sentence with a regular verb (using one of the above sentences) would be: I helped my friend. You simply helped your friend at some time in the past, but you might continue to help her at some point in the future. The same sentence with a past participle verb would be: I have helped my friend. You began helping your friend in the past and completed the action of helping her in the past. Past Participle of Irregular Verbs The past participle forms of  irregular verbs  have various endings, including  -d  (said),  -t  (slept), and  -n  (broken). Irregular verbs are trickier to form in the simple past than regular verbs, says Study.com, which gives these examples: Run   ranSing sangGo went To form the past participle of these irregular verbs, again precede them with an auxiliary verb: Ran has run, have runSing has sung, have sungWent has gone, have gone Common Irregular Past Participles Viewing some of the most common irregular verbs, together with the simple past as well as their past participle forms, can be helpful in understanding how they are formed. Verb Simple Past Past Participle fly flew have flown rise rose had risen shrink shrank had shrunk feel felt had felt bite bit has bitten catch caught have caught draw drew have drawn drive drove have driven eat ate have eaten fall fell have fallen Additionally, the verb  wear  is a classic example of an irregular verb that can be complicated to use as a past participle. You might  wear  underwear today if you are expressing action in the present. You  wore underwear yesterday if you are expressing the simple past. To use the same irregular verb as a past participle, however, you might say,  I  have  worn my Superman underwear. This implies that you donned your Superman underwear in the past but you are no longer doing so. Meanings and Forms of Past Participles The past participle can indicate past, present, and future meanings, according to Essentials of English: A Practical Handbook Covering All the Rules of English Grammar and Writing Style, which notes that the past participle has both perfect and progressive forms, as in: Thus deceived, he will be outraged. [Both actions are in the future.]Baffled by your attitude, I cannot help you. [Both actions are in the present.]Baffled by your attitude, I could not help you. [Both actions in the past.] In the first sentence above, the participle acts like an  appositive  adjective, renaming the subject  thief. The two actions occur completely in the future: The thief will be outraged and he  (will be) deceived. Note how the past participle includes an implied form of a to be verb:  will be. In the second sentence,  baffled  is still a past participle but the action will have been started and completed entirely in the present. The past participle includes an implied auxiliary verb- having been- so the full sentence would read: Having been baffled  by your attitude, I cannot help you. The action of being baffled starts and is completed entirely in the present, as is the (non)action of not helping.   In the same way, the third sentence starts with a past participle describing an action that started and was completed entirely in the past. The past participle also serves as an appositive adjective, describing the pronoun (and subject of the sentence).  The full sentence would read: Having been baffled  by your attitude, I could not help you. The  subjunctive  mood in the second half of the sentence describes an action- could not help- that happened (or in this case did not happen) entirely in the past. Sources Hopper, Vincent F. Essentials of English: A Practical Handbook Covering All the Rules of English Grammar and Writing Style. Barrons Educational Series, Cedric Gale, Ronald C. Foote, et al., Sixth edition, Barrons Educational Series, April 1, 2010.

The Problems of a Two Party System in the US Research Paper

The Problems of a Two Party System in the US - Research Paper Example Likewise, the first of these determinants which will be analyzed is with regards to the fact that the level of exasperation and frustration with the given paradigm seems to be ever-increasing. Although there are a number of factors which must be considered with regards to the overall level of support that the government engenders within the population, it must not be understated that the ineffectual nature in which the two-party system is exhibited over the past several decades is likely one of the causal components. Evidence of this can anecdotally be evidenced with regards to many of the polling results that a number of diverse entities has engaged in. The results of these nonpartisan polls have indicated that an increasing share of the American populace deals both disconnected and frustrated with politics as usual that is oftentimes exhibited at the regional levels. Such an eventuality is not surprising due to the fact that the two-party system necessarily divides people in an unn atural manner. When one stops to consider the fact that the United States is a multi religious, multi racial, multiethnic society, it comes as something of a curiosity that the two-party system has effectively been able to govern and represent an infinitely diverse level of needs and wants that such a vast and unheard modulus nation must necessarily engender.Another negative externality that the United States two-party system engenders within the current dynamic is with regards to the fact that the nation is currently in the midst of a wrenching difficult economic shift.... Evidence of this can anecdotally be evidenced with regards to many of the polling results that a number of diverse entities has engaged in. The results of these nonpartisan polls have indicated that an increasing share of the American populace deals both disconnected and frustrated with politics as usual that is oftentimes exhibited at the regional/state/federal levels. Such an eventuality is not surprising due to the fact that the two-party system necessarily divides people in an unnatural manner. When one stops to consider the fact that the United States is a multi religious, multi racial, multiethnic society, it comes as something of a curiosity that the two-party system has effectively been able to govern and represent an infinitely diverse level of needs and wants that such a vast and unheard modulus nation must necessarily engender. Although one may very well point to the fact that disagreement over economic policy, disagreement over involvement in foreign wars, or disagreement with regards to a litany of other social issues has helped to create an increasing level of frustration, the logical and to all of this is with regards to the fact that the frustration and dissatisfaction can ultimately be linked back to a general lack of creativity and problem solving that defines a ready-made two-party system. Another negative externality that the United States two-party system engenders within the current dynamic is with regards to the fact that the nation is currently in the midst of a wrenching and extraordinarily difficult economic shift. Whereas many decades the past history within the United States had been defined by an industrial era, the shift that is

Sociology - What is the difference betweex sex and gender How is this Essay

Sociology - What is the difference betweex sex and gender How is this distinction made - Essay Example Sex was â€Å"nature† and gender was â€Å"nurture†. In the language of Sociology, gender roles replaced sex roles, as gender represented more accurately than sex the social construction of identities and roles dividing societies into women and men. Sex and gender were interdependent, but clearly distinguished. Gender was social, thus variable and subject to change, while sex represented the essential and unchanging physical differences in human reproduction. An implicit causal link existed between sex and gender (Acker, 1992; Wilson, 1989). Feminist sociologists (e.g. Rossi, 1984) who took a biosocial view of gender, saw gender behaviour at least in part, as physiologically determined. They posited a clear distinction and a causal link between sex and gender. However, Acker (1992) states that variations in actions and feelings among both men and women, as well as similarities between women and men seemed too great, to permit the tracing of behaviour to biological differences. On the other hand, according to Butler (2005: 48), â€Å"because gender is fundamentally a way in which we make sense of ourselves as embodied creatures, no investigation of gender can allow itself to be carried too far off from the body. Gender reminds us that our bodies are not merely tools that we use to various ends. Our bodies are ourselves; their gender has a meaning and a value that is not merely instrumental†. In current usage gender is theorized as a basic principle of social structure and cultural interpretation (Scott, 1986; Acker, 1988). According to Unger (1979), gender refers to the traits and behaviors considered characteristic of and appropriate to members of each sexual category. These may be physiological, biosocial or environmental. In explaining gender as a constitutive element of social relationships, Scott (1986) emphasizes that â€Å"gender operates in multiple fields, including culturally

Media Studies Case Study Example | Topics and Well Written Essays - 2500 words

Media Studies - Case Study Example Advertising is persuasive and informational and is designed to influence the purchasing behavior and/or thought patterns of the audience. Advertising is a marketing tool and may be used in combination with other marketing tools, such as sales promotions, personal selling tactics, or publicity" (Advertising, p.1). In our everyday lives, we are surrounded by advertisements all over. It is nearly impossible to save ourselves from one or the other kind of advertisements whether it might be the most recent offer put forward by the local supermarket or perhaps even an advertisement on the television even if we stop reading the newspaper, stop watching television or even stride around with our eyes closed. As mentioned previously, the chief rationale of marketing is to advertise and sell products, but if one ponders, we come to realize the fact that the advertisement not only sells the product to people, but it also puts forward an image of our future which is extremely attractive and full of opportunities and advantages. For this particular essay, an advertisement will be analyzed with respect to semiotic terms and techniques and discourse analysis, and discover how denotation is constructed. The methods chosen for the analysis of the advertisement are the most appropriate methods. This is because through the semiotics and discourse analysis, the advertisement of Chrysler 300C chosen can be best analyzed as it contains the language and signs that require appropriate understanding and analysis that can only be done through the use of semiotics and discourse analysis.The next section presents the concepts of semiotics and discourse analysis that is discussed through the analysis of the literature present in different books, journals, periodicals and internet sources. The literature is reviewed through these sources and then discussed and critically analyzed. Semiotic and Discourse Analysis In the course of the method of being advertised, merchandise turns into an illustration of anything and everything that is desirable for the general public or at least the target market. The basic working of an advert basically is to indicate, to correspond to us, the object of our most unavoidable desires. We can therefore argue that the most important aspect of an advertisement is of what is important to us. For an advertisement to be successful it needs to put forward an image of us and to tell us ways by which we can use the product to make ourselves even more tempting, striking etc. In this way the product is given individuality, communicating to the target market not just plain information but also representation. The advert under consideration is the Chrysler 300C advertisement. The methods that have been taken up are known as Semiotics and Discourse Analysis. A commonsensical way to start here would be by defining Semiotics first. Basically, Semiotics was developed in the 1960s and has its roots in English literature and structural linguistics.

Ebola Virus: Structure, Pathogenesis and Treatment

Ebola Virus: Structure, Pathogenesis and Treatment Named after the river valley in Zaire, now known as the Democratic Republic of Congo, where it was first recognized, Ebola began its publicity in the spotlight of an epidemic. It is one of two members of RNA viruses called Filoviridae. Filoviridae were first discovered 9 years before the initial outbreak of Ebola, in 1967, in workers who were exposed to blood from African green monkeys imported from Uganda that had the Marburg virus [6]. The family Filoviridae constitutes, together with the families Paramyxoviridae and Rhabdoviridae, the order Mononegavirales. Within the family there is a single genus, filovirus, and a separation into two sero-/genotypes, Marburg and Ebola [6]. Filoviruses are classified as Biological Level 4agents [5] based on their high mortality rate, person-to-person transmission, potential for aerosol infectivity, and absence of vaccines and chemotherapy [6]. There are five identified subtypes of the Ebola virus. Four of the five have caused disease in humans: Ebola-Zaire, Ebola-Sudan, Ebola-Ivory Coast and Ebola-Bundibugyo. The fifth, Ebola-Reston, has caused disease only in primates [2]. In 1976, the first subtype of Ebola was discovered, Ebola-Zaire. A local was admitted to a hospital in Zaire with a fever. The nurse assumed he had malaria and gave him a quinine shot. When the patient went home he died and a traditional African funeral was organized. In preparation, the woman from his family removed the blood from his body with their bare hands; most of the women died shortly after [4]. Meanwhile, the nurses at the hospital reused the needle for the quinine injection without sterilizing it, spreading the virus to everyone who came in contact with it. A doctor was called in to show how to sterilize their needles, purify their water, and give tips on how to bury the bodies that were now piling up. Quarantine followed after an autopsy was performed on a corpse and was held until every person who had contracted the virus had died [4]. Ebola-Zaire spread through the hospitals through reused needles and dead bodies, claiming an average 82.6% fatality rate from 1976 to 2003 [5]. The Zaire strain claims the most outbreaks and highest fatality rate of any strain of Ebola virus, although, it is not the only strain to take lives. As the Ebola-Zaire strain was being discovered the Ebola-Sudan strain also emerged. The first case appeared in a worker exposed at a cotton factory. The second case caused the death of a nightclub owner when he was introduced to an unsterilized needle [4]. Scientists were able to isolate these events, but a reemergence in the same location cased a smaller epidemic to occur just 3 years later in 1979. It rested at an overall 53.76% fatality rate spanning from 1976 to 2003 [5]. Ebola-Reston caused disease in a group of Macaques; some of the people exposed to the virus developed antibodies and none became ill [1]. The Ebola-Ivory Coast strain has only one known case of infection, that of a scientist dissecting a wild chimpanzee in 1994. The scientist fully recovered from the strain. Given the low infection rate, Ebola virus natural habitat s to this day remain unknown [2]. Structure Seen through an electron micrograph, the Ebola virus appears as long rods, 800-1000 nanometers in length. The filamentous structure is often found in a distinguishing U-shape arrangement, but is pleomorphic; meaning it can take on many shapes. Other shapes include branched, circular, or a 6 shape. The outer envelope of the virion is covered in small spikes, made of virally encoded glycoproteins [12]. These spikes are 7nm long, spaced 10nm apart, and allow the virus to attach itself to host cells. Ebola virus is an enveloped negative-sense RNA virus which is associated with zoonotic infections in humans [8]. Its genome consists of a single-stranded molecule of non-segmented, negative-sense RNA. The RNA is noninfectious, not polyadenylated, and complementary to polyadenylated viral subgenomic RNA species [6]. Gene signals are distinct by transcriptional start signals at their 3à ¢Ã¢â€š ¬Ã‚ ² (3à ¢Ã¢â€š ¬Ã‚ ²-CUNCNUNUAAUU-5à ¢Ã¢â€š ¬Ã‚ ²) and the termination signals at their 5à ¢Ã¢â€š ¬Ã‚ ² (3à ¢Ã¢â€š ¬Ã‚ ²-UAAUUCUUUUU-5à ¢Ã¢â€š ¬Ã‚ ²) end [6]. The RNA is enclosed by a capsid known as the nucleocapsid. The nucleocapsid is formed by viral proteins, primarily VP24 and VP35. The space between the outer viral envelope and the nucleocapsid is known as the matrix space. Several viral proteins are located in the matrix space. Although little is known about the molecular mechanics of filoviruses, scientists focus on the mechanics of viral proteins as they are thought to function p rimarily as immune antagonists. Viral protein 24 (VP24), functions primarily to inhibit a signaling pathway known as JAK-STAT. The JAK-STAT pathway is a secondary method of transmitting information from chemical signals outside the cell, through the cellular membrane and into the cell. By inhibiting this signaling pathway, several cellular activities are disrupted including transcription. Studies have identified several regions within VP24 that are important for nucleocapsid formation [8]. As part of the bodys first line of defense against viral infections, interferons, which are released by lymphocytes during a non-specific immune response, disrupt a viruss ability to replicate. Viral protein 35 (VP35) is thought to play a central role in the synthesis of viral RNA, serving as an interferon antagonist [12]. The degree of interferon antagonist production is said to determine the pathogenicity of the virus and may account for the varying degrees of virulence among different strains of the Ebola virus [12]. Additionally, VP35 is critical for viral replication, suppression of RNA silencing, and nucleocapsid formation [8]. The viral protein 30 (VP30) is known to act as a transcription activator. Studies have suggested that VP30 halts the host cell transcription complex at its start site allowing the Ebola virus transcription to begin [13]. A nonstructural glycoprotein has only been discovered with viruses of the Ebola type. This protein, designated sGP, shares ~ 300 N-terminal amino acids with glycoprotein, but has a different C terminus (~70 amino acids) containing many charged residues as well as conserved cysteines [6]. Ebola virus glycoproteins, specifically the envelope-glycoprotein and the secretory-glycoprotein, play critical roles in the pathogenesis of the virus. The envelope-glycoprotein is responsible for receptor binding and fusion of the virus with host cells. Because Ebola is an enveloped virus, cleavage activation of membrane glycoproteins is essential for fusion between the viral envelope and the host cell membrane. This fusion allows the virus entry into host cells. The secretory-glycoprotein is secreted from infected cells [12]. Glycoproteins can also produce cytotoxicity by inducing cell rounding and detachment of cell surface integrins [9]. Specific cells targeted by Ebola virus differ depending on the strain of virus. Studies have shown glycoproteins of Zaire Ebola virus induced pathogenic changes in endothelial cells in both human and primate cells, where Reston Ebola virus glycoproteins induced similar effects in the primate cells but not in the human cells [12]. Endothelial cell dysfunction is thought to explain hemorrhagic characteristic of filovirus infections [12]. Often the proteins target the endothelial cells lining the blood vessel wall, which eventually leads to internal bleeding. Replication Replication of RNA viruses differ from that of DNA viruses in several ways. One important difference is that replication occurs in the cytoplasm of the host cell, and not in the nucleus. The virion then releases an enzyme into the cytoplasm, known as RNA-dependent RNA transcriptase, to begin transcription of positive-RNA. This positive strand of RNA then acts as the template for viral protein translation [7]. The virus proceeds to integrate itself into the DNA of the host cell allowing the viral RNA to become part of the host cells genetic material. The virus (at this point called a prophage) now can replicate every time the host cell replicates. Ebola virus replicates via both lysogenic and lytic phases. The lysogenic cycle is a process in which the virus enters the host cell but doesnt immediately destroy it. The virus enters through endocytosis in which the entire encapsidated virion is engulfed and released into the cytoplasm of the cell. After some time, the prophage is excised from the chromosome and the cell reenters the lytic phase, where the host cell lyses and newly assembled virions are released. At this point, symptoms of viral infection become evident [13]. Pathogenesis and Manifestation The Ebola causes the disease Ebola hemorrhagic fever. Within the first week of contracting the virus, mild headaches occur. The headaches intensify and flu-like symptoms, backache and chills are present. Fever, diarrhea, fatigue, and nausea then set in. Vomiting may occur within the first two weeks. By the end of two weeks, coughing and vomiting of blood occurs. Late symptoms arise. Blood purges from the mouth and rectum; eyes, ears, and nose follow. The eyes begin to inflame and the genitals swell. Rash overtakes the body, often containing blood. Seizures, coma, and delirium ensue. Death commonly comes from shock rather than blood loss [10]. Hemorrhaging is generally found macroscopically in most organ systems in human death scenarios. Focal necrosis in the liver, lymphatic organs, kidneys, testes, and ovaries are observed under a microscope. Incubation of the virus ranges from 2 to 21 days depending on the strain; the subtype Zaire is 4 to 16 days [6]. Treatment There is no known cure or standard treatment for Ebola hemorrhagic fever. Antivirals generally given to fight similar viral infections do not work well against the Ebola virus. Those who are infected can only receive supportive treatment for their symptoms until their body is able to fight off the virus. Most importantly, the patients blood volume and electrolytes are maintained to prevent the patient from going into shock. Fever, blood pressure, and oxygen levels are also monitored. The best option is to prevent infection through early diagnosis and isolation when outbreaks occur. Although cases are rare, vaccines can be a vital tool. Filoviruses can be harvested from wild monkeys in possibly infected areas to process for future vaccines. Epidemiology and Avoidance Since the natural reservoirs are unknown, prevention is merely suggestion. Wearing protective equipment such as gloves, masks, goggles, gowns, and practicing sterilization is recommended when in contact with the virus. When traveling to epidemic areas, its important to wear such equipment, and learn of possible symptoms as a preventive measure. The goal is to avoid contact with blood or secretions of any patient, as person-to-person contact is the main route of infection in human outbreaks. Premise concludes an infected animal is the primary determinant for contracting Ebola virus. Transmission can occur from direct contact with blood and/or secretions prevalent when caring for the infected [3]. History of the virus shows that nosocomial transmission provides high outbreak potential when sterilization is not practiced consistently. In lab setting, research suggests Ebola has the ability of spreading through airborne particles, but this type has not been documented among humans in a real-world setting [2]. In the case of a diagnosis, several infectious diseases need to be considered before making a proper diagnosis of filovirus. Detection can be done in the lab by measuring the host-specific immunological response to the infection, or by detecting viral antigens and genomic RNA in the infected host [6]. Conclusion The Ebola virus poses significant threat to humans and animals. Although the incidence of outbreak is low, the infection is very serious and often fatal. So far, Ebola has been confined and isolated but there is always a risk of it spreading rapidly to the rest of the world. Without effective treatment and prevention the threat is enhanced. More extensive knowledge is needed to understand how the virus spreads and its development, specifically Ebolas natural reservoir. Therefore, while traveling the world, people should be aware of the threats from the Ebola virus in order to avoid infection, and hopefully scientists will do their best to develop a treatment and vaccination. McDonalds in Beijing: Localization of Americana McDonalds in Beijing: Localization of Americana Summary: According to me the Author talks about the recent changes in the Chinese society and the new tendency to adopt the foreign culture influences and transform them into local institution which was restricted by the Chinese political system during the Maoist era. The important points made in the article are as follows: Acceptance of foreign culture influences. Beijing customers are the active partners in the process of localisation. Representation of McDonalds as Americana and the promise of modernisation. People patronize McDonalds to experience a moment of equality. Making experience at McDonalds restaurants exotic, American, and to a certain extent, modern. Genuineness of McDonalds food that is being identical to its American counterpart. Attraction to McDonalds by its American style rather then its food. McDonalds interpretation of its food as a foreign form of xianbing. The culture of fast food attracting the Beijing consumers. A way to take part in transnational cultural system. At McDonalds, eating environment is considered as romantic and comfortable. McDonalds experience is treated as a chance to explore American culture and give their young one a special treat. McDonalds representation as a symbol of American Culture has led them to accept new patterns of behaviour. Willingness to accept the exotic culture and social behaviour in general. McDonalds treated as a place to gain status. Efforts made to adapt Chinese cultural settings. McDonalds as a place to hang out McDonalds creating a family atmosphere for Beijing customers. Personal interaction with customers. Beijing customers want their children to learn American culture. Finally the author concludes saying, McDonalds has transformed into middle class family establishment, where people can enjoy their leisure time and experience a Chinese version of American culture. Critical Review I think that the article is relevant in todays world and the localization process mentioned by the author in the article. For any multinational company it is necessary that they try to adopt the home countrys culture i.e. tries to bring the home culture in their goods and services. As said by Mingsheng Li, a senior lecturer in the Department of Communication, Journalism and Marketing at Massey University in Wellington, New Zealand, the degree of localization largely determines the degree to which a business succeeds or fails in a given country. The more the company works toward localization, the more likely it will be successful. It is necessary to understand ones culture and traditions and respect their tastes. But what is localization? To attract the target market, a product is made linguistically and it is culturally appropriate. When a company plans for global expansion, it is involved in the process of communication with local customers. Therefore it is necessary for the company to get familiar with local culture, study different customs, and make proper adjustments to their strategies according to the varied response of customers. The best example would be McDonalds in India. Majority of people in India are vegetarian. So McDonalds introduced range of vegetarian food in their outlet with the added flavor of American culture in it. McDonalds also priced their product according to the income of common people in India. Indian consumers were aware f the fast food culture, but the fast food in India was unhealthy and unhygienic. Introduction of McDonalds in India brought about the change in the fast food culture of India. The burgers were priced at Rs 20 which was affordable for an average middle class family. If McDonalds did not adopted localization strategy in China i.e. if they did not adopted the Chinese culture and traditions and the consumers taste, it was a failed project and the people of china would have banned it just like the French company Carrefour, hypermarket chain with more than 100 stores in major cities in China. The company had donated a large sum of money to the Dalai Lama. Calling for a boycott against French goods, Chinese nationals also called for a boycott against tourist travel to France. (Mingsheng Li, a senior lecturer in the Department of Communication, Journalism and Marketing at Massey University in Wellington, New Zealand). According to the article presented by the author it talks about the recent changes in the Chinese society and the new tendency to adopt the foreign culture influences and transform them into local institution which was restricted by the Chinese political system during the Maoist era. I strongly agree with the article and its process of localization strategy. The brand name of McDonalds was already there in the minds of Beijing customers. And before the McDonalds entered the Chinese market, the people of Beijing were fond of the American style and its culture. They were keen to learn the American or the Western culture. And when McDonalds entered the Chinese market on 23rd of April 1992, it served more than 40000 customers on the first day. This shows that the Beijing consumers were waiting for such kind of change in China, where they can experience the American or the Western culture. McDonalds has always been a fast food restaurant. The fast food in China was expensive and unhealthy. As mentioned in the article, in the eyes of the Beijing customers McDonalds represents Americana and the promise of modernisation. People also patronize McDonalds to experience the moment of equality. But McDonalds mad sure that they follow Chinese culture and Tradition and also keep up with the taste of the consumers to be successful in Chinese market. Some of the strategy adopted by McDonalds to attract the customer is Online chats Madden, Normandy; Wentz, Laurel. Advertising Age, 7/31/2006. For its its growth strategy in mainland China, McDonalds has created a live online chat series with the popular portal Sina and Askme.com.cn, a website launched by McDonalds in the mainland. Consumers can interact with leading sports, entertainment and business figures. The first one-hour episode Aug. 1 in Beijing will feature Houston Rockets basketball star and Shanghai, China, native Yao Ming, who signed a multiyear global partnership deal with McDonalds in 2004. The online initiative has no target age group, The program aims to provide consumer-focused education and encourage active, balanced lifestyles, but also be seen as an effort to ward off potential concerns about the nutritional content of fast food in general in China. Opens drive-through in China Madden, Normandy, Wentz, Laurel, Advertising Age, 00018899, 1/30/2006. Chinas rapid transformation into a car culture had led McDonalds to open drive thru in China. Drive-through sites, which account for a large proportion of McDonalds sales in the U.S., reflect Chinas rapid transformation into a car culture. With almost 6 million automobile sales last year, China has surpassed Japan and is now second only to the U.S. in annual car sales in the year 2006. This kind of strategy is a sign of bringing the American culture in China. But they are keeping in mind about the culture and traditions of China.

The Civil Wars Tragic Legacy :: United States History Papers

The Civil War's Tragic Legacy The Civil War produced at least two important outcomes. First, although it was not President Lincoln's intent, it freed slaves in the Confederate States. Second, it settled, through the force of arms, the question of whether states could secede from the Union. The causes of and the issues surrounding America's most costly war, in terms of battlefield casualties, are still controversial. Even its name the - Civil War - is in dispute, and plausibly so. A civil war is a struggle between two or more factions seeking to control the central government. Modern examples of civil wars are the conflicts we see in Lebanon, Liberia and Angola. In 1861, Jefferson Davis, the President of the Confederate States, no more wanted to take over Washington, D.C. than George Washington wanted to take over London in 1776. George Washington and the Continental Congress were fighting for independence from Great Britain. Similarly, the Confederate States were fighting for independence from the Union. Whether one's sentiments lie with the Confederacy or with the Union, a more accurate characterization of the war is that it was a war for southern independence; a frequently heard southern reference is that it was the War of Northern Aggression. History books most often say the war was fought to free the slaves. But that idea is brought into serious question considering what Abraham Lincoln had to say in his typical speeches: "I have no purpose, directly or indirectly, to interfere with the institution of slavery in the states where it exists. I believe I have no lawful right to do so, and I have no inclination to do so." Slavery makes for great moral cause celebre for the War Between the States but the real causes had more to do with problems similar to those the nation faces today - a federal government that has escaped the limits the Framers of the Constitution envisioned. South Carolina Senator John C Calhoun expressed that concern in his famous Fort Hill Address July 26, 1831, at a time when he was Andrew Jackson's vice-president. Calhoun said, "Stripped of all its covering, the naked question is, whether ours is a federal or consolidated government; a constitutional or absolute one; a government resting solidly on the basis of the sovereignty of the States, or on the unrestrained will of a majority; a form of government, as in all other unlimited ones, in which injustice, violence, and force must ultimately prevail.

Mind Muscle Connection

I have put together a brief summary of how important a mind muscle connection is, and have touched on the following topics in chronological order: 1) Introduction 2) Currect ‘bro-split' analysis and effectiveness 3) Examples of optimising the mind-muscle connection 4) Defined example – brought out of context 5) Defined example – put back into context 6) A scientific approach 7) A scientific approach – taken out of context 8) The importance of myelin ) Myelin and skill 10) Conclusion In order to build muscle for example, one must gain an efficient mind muscle connection – therefore more experienced bodybuilders have adapted a stronger neurological connection between their mind and the muscle group they have chosen to work out. Thus, by doing a chest/tri split your mind muscle connection is ‘active' during the chest phase of the workout, since you're getting the muscle pumped before breaking it down.However, regarding the tris part, the muscle is already pumped subliminally through it being a secondary muscle group when working out chest. Therefore IMO, a more effective split, for example, would be chest/bis since you are initiating mental focus twice as opposed to once. if that makes any sence? In order to substantiate my aforementioned point regarding a mind-muscle connection I put forward the idea of the disabled: Taken out of context in order to further develop a holistic view, we analyse a blind man.Since this person has lost one of his senses he is much more dependant on other senses such as touch for example. Therefore the mind muscle connection has created strong links between the brain/nervous system and nerves in his fingers (braille) to ensure the human flys (recalling upon both the fight or flight theory and Darwin's natural selection – and also a point that Tread-m touched upon in his most recent post, the Causality Paradigm – Cause and Effect ).Now, if we put this back into context, a bodybuilder would aim to develop/enhance their mind-muscle connection to further the efficiency of their muscle growth, as it has proven to be beneficial through the simple analytical awareness of the target muscle group and the overall objective, thus creating a synergistic harmonious benefit. Also, neurological changes – ultimately the nervous system is responsible for ‘recruiting’ muscle fibers.In simple terms the nervous system stimulates a muscle to contract by sending down electrical impulses towards the muscle. Scientists can measure the ability of the nervous system to stimulate muscle by measuring its electrical activity. In order to optimise the mind-muscle connection, more myelin must be created (Myelin is the insulation for nerve fibres – think of this as the rubber which insulates your household electrical appliances) – thus, the more myelin, the stronger and more accurate the electrical activity will be.Every human skill, regardless of which acti vity it is (for example, playing soccer, playing a musical instrument, running in a 100 metre sprint) is created by thousands chains of nerve fibres carrying an electrical pulse – resulting in a signal being transmitted from a source (CNS – Central Nervous System)to the muscles required to perform a specific task. The role of myelin is to embrace and wrap around the nerves carrying the signal in order to ensure that the signal level is efficient – thus reducing the amount of electrical impulse being leaked outside of the intended destination.Thus, upon practising (through bodybuilding repetitions, for example) our neurological circuits are continuously firing and through repetitions, our brain signals send messages to ensure each correctly fired signal's nerve is insulated more and more – (think of this as if the more myelin there is insulating your nerve fibres, the more efficient you are at performing that specific movement). Myelin is very important fo r many reasons. Everyone can produce it – and it is produced more efficiently during our childhood years (which is why it is considered easier to pick up a skill/talent in our youth than in our senior years).Additionally, its indiscriminate – and growth can be a result of both mental and physical actions. Myelin is therefore an inhibitor of skill – whereby skill is defined as â€Å"a cellular insulation that wraps neural circuits and that grows in response to certain signals† (Coyle, D. , 2009) – thus, through the analysis of the aforementioned quote, the more time and energy you administer with achieving a certain skill-set – the more efficient and effective you become at it (substantiated by the common phrase practise makes perfect).

Advantages and Disadvantages of Free Higher Education Essay

College and university education has become very important in today’s life. Wherever you see an advertisement for job, there is some certain criteria for certain posts. For example for marketing executive employers prefer MBA Marketing person, for eye surgeons hospitals prefer oculist. Without a college degree a person is unqualified for such posts. Some people believe that university graduates should pay the full cost of their education. Others say that university education should be free. Let’s consider advantages and disadvantages. On the one hand, higher education leads to a more educated and productive workforce and it does offer some external benefits to society Also, everybody will get an equal chance to pursue higher studies, independent of their economic background and enabling merit to become the sole criteria. If the education is given free to all then admission will be given wholly on merit basis. This will result in increase in level of competition. It will be certainly beneficial to everybody those who could get admissions. Brilliant students will build a strong nation. On the other hand, if people have to pay to go to university, they would value the education more. In this situation, students motivation for achieving good performance is expected to be high. Then, if the government of a country takes policy to fully finance the college education, the government has to limit the number of colleges and universities since their budget is not limitless and it will produce many problems. And Top up fees enable more investment in universities. It will also help attract and keep the best teachers and researchers. This issue has both positive and negative sides as we saw above. The best thing will be to make the education free for those who are economically backward, are really incapable of paying fees for education but they have caliber. But education should not be made free to people who are rich and are capable paying fees for their kids. This will really help to reduce the economical differences in society as poor will be able to get good jobs.

010 Peer Review and Intros Professor Ramos Blog

010 Peer Review and Intros Quick Write Quick Write Who is your audience? Who are you trying to convince with your argument? Introductions Introductions are very important. An introduction has to make a good impression, grab your reader’s interest, and make them want to keep reading. We will focus on starting our essays with a story. Focus on getting your readers attention, and making them care, so that they will want to keep reading. Using Rhetoric Notes Ethos Research Unbiased Pathos Emotional Storytelling So What? Logos Logical History Facts Statistics Evidence Authority/Pros Background Include the Conversation Peer Review . Argument –  a reason or set of reasons given with the aim of persuading others that an action or idea is right or wrong. Remember, an argument uses reasons and evidence to persuade. Have you provided enough reasons and evidence to convince us of your position? Keep these things in mind. Peer edit the same way you revise your own work. Be specific in identifying problems or opportunities. Offer suggestions for improvement. Praise what is genuinely good in the paper. Check for: Is the writer’s tone appropriate? Who is the audience? Looking at the essay as a whole, what is the thesis or main idea? Is each paragraph adequately developed? Are there sufficient details and/or   supporting quotations? For the Proposal, make sure you: Define the problem Recognize an audience Create, explain, and justify a plan of action. Persuade readers of the problem and proposed solution. Quick Write What is your plan of action for revising your essay?

My Visit to Philadelphia's Museum of Art Essay Example | Topics and Well Written Essays - 500 words

My Visit to Philadelphia's Museum of Art - Essay Example The classic architecture of the building made me spellbound. It is a well designed building with huge stone columns and elegantly designed staircase. I must add that visiting this art museum was a life time experience for me. The museum is systematically organized in various galleries in different directions. The museum holds different major art works unlike other museums which highlights its significance housing some of the excellent artworks by known artists such as Claude Mont, Edouard Manet, Renoir, Cassat and many more. The art collections of these mastered painters are housed in the gallery of â€Å"European Art 1850-1900.† Therefore, the art museum of Philadelphia is basically known for housing some of the best impressionist collection. One fine piece of work that captured by attention is an artwork by Edgar Degas which is known as â€Å"The Ballet Class.† Edgar has represented the life of Ballet dancers behind the class in a very expressive way. The Ballet dance rs are depicted in every phase of their lives; somewhere he has shown a woman waiting impatiently and ballerinas performing. This artwork grabs the attention of the viewers for being close to the difficult real life experiences that ballet dancers are usually faced with in their dancing lives. In other words we can say that this represents the true picture of real life difficulties in one’s life. However, it is one of my favorite piece of artwork. After carefully examining the impression collection I moved to modern gallery which has some of the very fine collections by the modern painters such as Pollack, Motherwell, Rothko and so on. It was worth examining the artwork by Cy Twomby. We cannot ignore the fact the modern art studies is incomplete without discussing the Cy Twombly’s famous ten-work series which holds a great importance in shaping the modern art. Twombly has best represented the battle between the Greeks and the Trojans in its

Diplomatic Immunity Essay Example | Topics and Well Written Essays - 1500 words

Diplomatic Immunity - Essay Example Yet because of ambiguities in the interpretation of the said international agreement, abuses of diplomatic immunities have become inevitable. These abuses of power and privilege range from petty crimes like traffic violations and debt to more serious crimes of conspiracy, rape, and murder. Because of this, efforts to clarify the extent and provisions of Diplomatic Immunity should take place. This paper will then attempt to provide suggestions on how to resolve and prevent abuses of diplomatic immunities. Diplomatic immunity, as agreed upon by the standards of international law, is a form of legal exemption extended to a country's diplomats. This entitles the diplomats and their immediate families to be exempted from the laws and local courts of the host country. Some of the general provisions of diplomatic immunity guarantee that the diplomats and their immediate families: "may not be arrested or detained, may not have their residences entered or searched, may not be subpoenaed as witnesses, and may not be prosecuted." (eDiplomat, 2006) The 1958 Yearbook of International Law Commission, as cited in Vrk (2003), mentions three theories about the legal bases of diplomatic immunity. ... ntatives of a sending state, the diplomats should also be given the same independence as a receiving state would have negotiated with the sending state itself. These two theories, of course, have long been deduced to legal fictions with all the faulty assumptions. The accepted theory behind diplomatic immunity now lies in the "theory of functional necessity." This theory is based on the need of diplomatic missions and diplomats to efficiently perform their duties and responsibilities according to what their country requires from them, without apprehensions of being criminally charged by the receiving state. For instance, diplomats are able to initiate unfounded penal proceedings without hindrances from the receiving state because of diplomatic immunity. According to eDiplomat (2006), "Diplomatic immunity is not meant to benefit individuals personally; it is meant to ensure that foreign officials can do their jobs. Under the concept of reciprocity, diplomats assigned to any country in the world benefit equally from diplomatic immunity." This assumption that diplomatic immunity would be reciprocally observed between sovereign states justifies the seemingly biased scales of justice. The rationale why countries agree to be dependent on a foreign country's decision before prosecuting a diplomat in their own territory is based on the fact that these countries are both receiving and sending diplomats. This means that they also have their own diplomats' immunity at stake in different countries across the globe. It is clearly stated in the preamble of the Vienna Convention on Diplomatic Relations that "the purpose of such privileges and immunities is not to benefit individuals but to ensure the efficient performance of the functions of diplomatic missions as representing